Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters
Identifieur interne : 000687 ( new/Analysis ); précédent : 000686; suivant : 000688Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters
Auteurs : Ya Zhao [République populaire de Chine] ; Limin Feng [République populaire de Chine] ; Lijuan Liu [République populaire de Chine] ; Ruizhi Zhao [République populaire de Chine]Source :
- Life Sciences [ 0024-3205 ] ; 2019.
Abstract
Aims: Vinegar-baked
Main methods: The activities of transporters were analyzed by concentration of their cellular substrates. Concentrations of colchicine (substrate of Pgp and MRP1) and cisplatin (substrate of OCT2 and MRP2) were determined by high-performance liquid chromatography (HPLC). The concentration of rhodamine B was determined by flow cytometry. The expression of transporter gene and protein were determined by qRT-PCR and Western blotting analysis.
Key findings: SSb2 increased colchicine efflux in HEK293 cells by primarily increasing Mrp1 activity, independent of gene and protein expression. SSb2 enhanced Mrp2 function and increased cisplatin efflux in BRL3A cells by upregulating Mrp2 gene expression, with a marginal effect on Pgp in normal cells. SSb2 increased OCT2 activity in OCT2-HEK293 cells by increasing the expression of OCT2 protein and mRNA; however, SSb2 inhibited MRP2 activity in MRP2-HEK293 cells by decreasing MRP2 protein expression, and decreased Pgp and MRP1 activity in Pgp- and MRP1-HEK293 cells.
Significance: SSb2 might potentially be the key active component of VBRB that enhances the hepatotargeting of anticancer drugs through the inhibition of multidrug resistance-associated drug transporters (Pgp, MRP1, and MRP2) in an environment-dependent manner.
Url:
DOI: 10.1016/j.lfs.2019.116557
PubMed: 31194994
PubMed Central: 7094655
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000952
- to stream Pmc, to step Curation: 000952
- to stream Pmc, to step Checkpoint: 000235
- to stream Ncbi, to step Merge: 000870
- to stream Ncbi, to step Curation: 000870
- to stream Ncbi, to step Checkpoint: 000870
- to stream Main, to step Merge: 000D26
- to stream Main, to step Curation: 000D24
- to stream Main, to step Exploration: 000D24
- to stream new, to step Extraction: 000687
Links to Exploration step
PMC:7094655Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters</title><author><name sortKey="Zhao, Ya" sort="Zhao, Ya" uniqKey="Zhao Y" first="Ya" last="Zhao">Ya Zhao</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Feng, Limin" sort="Feng, Limin" uniqKey="Feng L" first="Limin" last="Feng">Limin Feng</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Lijuan" sort="Liu, Lijuan" uniqKey="Liu L" first="Lijuan" last="Liu">Lijuan Liu</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Ruizhi" sort="Zhao, Ruizhi" uniqKey="Zhao R" first="Ruizhi" last="Zhao">Ruizhi Zhao</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31194994</idno><idno type="pmc">7094655</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7094655</idno><idno type="RBID">PMC:7094655</idno><idno type="doi">10.1016/j.lfs.2019.116557</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000952</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000952</idno><idno type="wicri:Area/Pmc/Curation">000952</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000952</idno><idno type="wicri:Area/Pmc/Checkpoint">000235</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000235</idno><idno type="wicri:Area/Ncbi/Merge">000870</idno><idno type="wicri:Area/Ncbi/Curation">000870</idno><idno type="wicri:Area/Ncbi/Checkpoint">000870</idno><idno type="wicri:doubleKey">0024-3205:2019:Zhao Y:saikosaponin:b:enhances</idno><idno type="wicri:Area/Main/Merge">000D26</idno><idno type="wicri:Area/Main/Curation">000D24</idno><idno type="wicri:Area/Main/Exploration">000D24</idno><idno type="wicri:Area/new/Extraction">000687</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters</title><author><name sortKey="Zhao, Ya" sort="Zhao, Ya" uniqKey="Zhao Y" first="Ya" last="Zhao">Ya Zhao</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Feng, Limin" sort="Feng, Limin" uniqKey="Feng L" first="Limin" last="Feng">Limin Feng</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Liu, Lijuan" sort="Liu, Lijuan" uniqKey="Liu L" first="Lijuan" last="Liu">Lijuan Liu</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author><author><name sortKey="Zhao, Ruizhi" sort="Zhao, Ruizhi" uniqKey="Zhao R" first="Ruizhi" last="Zhao">Ruizhi Zhao</name><affiliation wicri:level="1"><nlm:aff id="af0005">Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Department of Chinese Medicine Property Team, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome, the Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Neihuan Xilu, Guangzhou Higher Education Mega Center, Guangzhou 510006</wicri:regionArea><placeName><settlement type="city">Jiangmen</settlement><region type="province">Guangdong</region></placeName></affiliation></author></analytic><series><title level="j">Life Sciences</title><idno type="ISSN">0024-3205</idno><idno type="eISSN">1879-0631</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Aims: Vinegar-baked <italic>Radix Bupleuri</italic> (VBRB) potentiates the activity of anticancer drugs in the liver by increasing their hepatic distribution. However, this phenomenon may be associated with drug transporters. We investigated the effect of saikosaponin b2 (SSb2; the main component of VBRB) on the activity and expression of different drug transporters in both normal cells and those that overexpress the transporter.</p><p>Main methods: The activities of transporters were analyzed by concentration of their cellular substrates. Concentrations of colchicine (substrate of Pgp and MRP1) and cisplatin (substrate of OCT2 and MRP2) were determined by high-performance liquid chromatography (HPLC). The concentration of rhodamine B was determined by flow cytometry. The expression of transporter gene and protein were determined by qRT-PCR and Western blotting analysis.</p><p>Key findings: SSb2 increased colchicine efflux in HEK293 cells by primarily increasing Mrp1 activity, independent of gene and protein expression. SSb2 enhanced Mrp2 function and increased cisplatin efflux in BRL3A cells by upregulating Mrp2 gene expression, with a marginal effect on Pgp in normal cells. SSb2 increased OCT2 activity in OCT2-HEK293 cells by increasing the expression of OCT2 protein and mRNA; however, SSb2 inhibited MRP2 activity in MRP2-HEK293 cells by decreasing MRP2 protein expression, and decreased Pgp and MRP1 activity in Pgp- and MRP1-HEK293 cells.</p><p>Significance: SSb2 might potentially be the key active component of VBRB that enhances the hepatotargeting of anticancer drugs through the inhibition of multidrug resistance-associated drug transporters (Pgp, MRP1, and MRP2) in an environment-dependent manner.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Cheung, F" uniqKey="Cheung F">F. Cheung</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Wang, N" uniqKey="Wang N">N. Wang</name></author><author><name sortKey="Yuen, M F" uniqKey="Yuen M">M.F. Yuen</name></author><author><name sortKey="Ziea, T C" uniqKey="Ziea T">T.C. Ziea</name></author><author><name sortKey="Tong, Y" uniqKey="Tong Y">Y. Tong</name></author><author><name sortKey="Wong, V T" uniqKey="Wong V">V.T. Wong</name></author><author><name sortKey="Feng, Y" uniqKey="Feng Y">Y. Feng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, R Z" uniqKey="Zhao R">R.Z. Zhao</name></author><author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y.J. Chen</name></author><author><name sortKey="Cai, J X" uniqKey="Cai J">J.X. Cai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, R Z" uniqKey="Zhao R">R.Z. Zhao</name></author><author><name sortKey="Yuan, D" uniqKey="Yuan D">D. Yuan</name></author><author><name sortKey="Liu, S J" uniqKey="Liu S">S.J. Liu</name></author><author><name sortKey="Chen, Y J" uniqKey="Chen Y">Y.J. Chen</name></author><author><name sortKey="Liu, L J" uniqKey="Liu L">L.J. Liu</name></author><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, R Z" uniqKey="Zhao R">R.Z. Zhao</name></author><author><name sortKey="Liu, S J" uniqKey="Liu S">S.J. Liu</name></author><author><name sortKey="Mao, S R" uniqKey="Mao S">S.R. Mao</name></author><author><name sortKey="Wang, Y J" uniqKey="Wang Y">Y.J. Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ye, R P" uniqKey="Ye R">R.P. Ye</name></author><author><name sortKey="Chen, Z D" uniqKey="Chen Z">Z.D. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lorrai, I" uniqKey="Lorrai I">I. Lorrai</name></author><author><name sortKey="Maccioni, P" uniqKey="Maccioni P">P. Maccioni</name></author><author><name sortKey="Carai, M A" uniqKey="Carai M">M.A. Carai</name></author><author><name sortKey="Capra, A" uniqKey="Capra A">A. Capra</name></author><author><name sortKey="Castelli, M P" uniqKey="Castelli M">M.P. Castelli</name></author><author><name sortKey="Riva, A" uniqKey="Riva A">A. Riva</name></author><author><name sortKey="Morazzoni, P" uniqKey="Morazzoni P">P. Morazzoni</name></author><author><name sortKey="Gessa, G L" uniqKey="Gessa G">G.L. Gessa</name></author><author><name sortKey="Colombo, G" uniqKey="Colombo G">G. Colombo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Y" uniqKey="Li Y">Y. Li</name></author><author><name sortKey="Cai, T" uniqKey="Cai T">T. Cai</name></author><author><name sortKey="Zhang, W" uniqKey="Zhang W">W. Zhang</name></author><author><name sortKey="Zhu, W" uniqKey="Zhu W">W. Zhu</name></author><author><name sortKey="Lv, S" uniqKey="Lv S">S. Lv</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, C" uniqKey="Li C">C. Li</name></author><author><name sortKey="Guan, X" uniqKey="Guan X">X. Guan</name></author><author><name sortKey="Xue, H" uniqKey="Xue H">H. Xue</name></author><author><name sortKey="Wang, P" uniqKey="Wang P">P. Wang</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Gai, X" uniqKey="Gai X">X. Gai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, T H" uniqKey="Lee T">T.H. Lee</name></author><author><name sortKey="Chang, J" uniqKey="Chang J">J. Chang</name></author><author><name sortKey="Kim, B M" uniqKey="Kim B">B.M. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, Z Y" uniqKey="Li Z">Z.Y. Li</name></author><author><name sortKey="Sun, H M" uniqKey="Sun H">H.M. Sun</name></author><author><name sortKey="Xing, J" uniqKey="Xing J">J. Xing</name></author><author><name sortKey="Qin, X M" uniqKey="Qin X">X.M. Qin</name></author><author><name sortKey="Du, G H" uniqKey="Du G">G.H. Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jiang, H" uniqKey="Jiang H">H. Jiang</name></author><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Shi, R B" uniqKey="Shi R">R.B. Shi</name></author><author><name sortKey="Yin, W P" uniqKey="Yin W">W.P. Yin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Wang, Y J" uniqKey="Wang Y">Y.-J. Wang</name></author><author><name sortKey="Zhao, R Z" uniqKey="Zhao R">R.-Z. Zhao</name></author><author><name sortKey="Xiang, F J" uniqKey="Xiang F">F.-J. Xiang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shitara, Y" uniqKey="Shitara Y">Y. Shitara</name></author><author><name sortKey="Horie, T" uniqKey="Horie T">T. Horie</name></author><author><name sortKey="Sugiyama, Y" uniqKey="Sugiyama Y">Y. Sugiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, Y" uniqKey="Zhao Y">Y. Zhao</name></author><author><name sortKey="Feng, L M" uniqKey="Feng L">L.M. Feng</name></author><author><name sortKey="Liu, L J" uniqKey="Liu L">L.J. Liu</name></author><author><name sortKey="Zhang, X" uniqKey="Zhang X">X. Zhang</name></author><author><name sortKey="Zhao, R Z" uniqKey="Zhao R">R.Z. Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, P W" uniqKey="Cheng P">P.W. Cheng</name></author><author><name sortKey="Ng, L T" uniqKey="Ng L">L.T. Ng</name></author><author><name sortKey="Chiang, L C" uniqKey="Chiang L">L.C. Chiang</name></author><author><name sortKey="Lin, C C" uniqKey="Lin C">C.C. Lin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, L T" uniqKey="Lin L">L.T. Lin</name></author><author><name sortKey="Chung, C Y" uniqKey="Chung C">C.Y. Chung</name></author><author><name sortKey="Hsu, W C" uniqKey="Hsu W">W.C. Hsu</name></author><author><name sortKey="Chang, S P" uniqKey="Chang S">S.P. Chang</name></author><author><name sortKey="Hung, T C" uniqKey="Hung T">T.C. Hung</name></author><author><name sortKey="Shields, J" uniqKey="Shields J">J. Shields</name></author><author><name sortKey="Russell, R S" uniqKey="Russell R">R.S. Russell</name></author><author><name sortKey="Lin, C C" uniqKey="Lin C">C.C. Lin</name></author><author><name sortKey="Li, C F" uniqKey="Li C">C.F. Li</name></author><author><name sortKey="Yen, M H" uniqKey="Yen M">M.H. Yen</name></author><author><name sortKey="Tyrrell, D L" uniqKey="Tyrrell D">D.L. Tyrrell</name></author><author><name sortKey="Lin, C C" uniqKey="Lin C">C.C. Lin</name></author><author><name sortKey="Richardson, C D" uniqKey="Richardson C">C.D. Richardson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ma, H" uniqKey="Ma H">H. Ma</name></author><author><name sortKey="Yokoyama, S" uniqKey="Yokoyama S">S. Yokoyama</name></author><author><name sortKey="Saiki, I" uniqKey="Saiki I">I. Saiki</name></author><author><name sortKey="Hayakawa, Y" uniqKey="Hayakawa Y">Y. Hayakawa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Y X" uniqKey="Zhang Y">Y.X. Zhang</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author><author><name sortKey="Li, X" uniqKey="Li X">X. Li</name></author><author><name sortKey="Peng, S" uniqKey="Peng S">S. Peng</name></author><author><name sortKey="Wang, S F" uniqKey="Wang S">S.F. Wang</name></author><author><name sortKey="Huang, C Z" uniqKey="Huang C">C.Z. Huang</name></author><author><name sortKey="Huang, C Z" uniqKey="Huang C">C.Z. Huang</name></author><author><name sortKey="Zhang, Q" uniqKey="Zhang Q">Q. Zhang</name></author><author><name sortKey="Li, D" uniqKey="Li D">D. Li</name></author><author><name sortKey="Jiang, J" uniqKey="Jiang J">J. Jiang</name></author><author><name sortKey="Ouyang, Q" uniqKey="Ouyang Q">Q. Ouyang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Priyamvada, S" uniqKey="Priyamvada S">S. Priyamvada</name></author><author><name sortKey="Anwar, M" uniqKey="Anwar M">M. Anwar</name></author><author><name sortKey="Kumar, A" uniqKey="Kumar A">A. Kumar</name></author><author><name sortKey="Anbazhagan, A N" uniqKey="Anbazhagan A">A.N. Anbazhagan</name></author><author><name sortKey="Gill, R K" uniqKey="Gill R">R.K. Gill</name></author><author><name sortKey="Alrefai, W A" uniqKey="Alrefai W">W.A. Alrefai</name></author><author><name sortKey="Dudeja, P K" uniqKey="Dudeja P">P.K. Dudeja</name></author><author><name sortKey="Saksena, S" uniqKey="Saksena S">S. Saksena</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kim, H G" uniqKey="Kim H">H.G. Kim</name></author><author><name sortKey="Hien, T T" uniqKey="Hien T">T.T. Hien</name></author><author><name sortKey="Han, E H" uniqKey="Han E">E.H. Han</name></author><author><name sortKey="Hwang, Y P" uniqKey="Hwang Y">Y.P. Hwang</name></author><author><name sortKey="Choi, J H" uniqKey="Choi J">J.H. Choi</name></author><author><name sortKey="Kang, K W" uniqKey="Kang K">K.W. Kang</name></author><author><name sortKey="Kwon, K I" uniqKey="Kwon K">K.I. Kwon</name></author><author><name sortKey="Kim, B H" uniqKey="Kim B">B.H. Kim</name></author><author><name sortKey="Kim, S K" uniqKey="Kim S">S.K. Kim</name></author><author><name sortKey="Song, G Y" uniqKey="Song G">G.Y. Song</name></author><author><name sortKey="Jeong, T C" uniqKey="Jeong T">T.C. Jeong</name></author><author><name sortKey="Jeong, H G" uniqKey="Jeong H">H.G. Jeong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seo, S B" uniqKey="Seo S">S.B. Seo</name></author><author><name sortKey="Hur, J G" uniqKey="Hur J">J.G. Hur</name></author><author><name sortKey="Kim, M J" uniqKey="Kim M">M.J. Kim</name></author><author><name sortKey="Lee, J W" uniqKey="Lee J">J.W. Lee</name></author><author><name sortKey="Kim, H B" uniqKey="Kim H">H.B. Kim</name></author><author><name sortKey="Bae, J H" uniqKey="Bae J">J.H. Bae</name></author><author><name sortKey="Kim, D W" uniqKey="Kim D">D.W. Kim</name></author><author><name sortKey="Kang, C D" uniqKey="Kang C">C.D. Kang</name></author><author><name sortKey="Kim, S H" uniqKey="Kim S">S.H. Kim</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hipfner, D R" uniqKey="Hipfner D">D.R. Hipfner</name></author><author><name sortKey="Deeley, R G" uniqKey="Deeley R">R.G. Deeley</name></author><author><name sortKey="Cole, S P" uniqKey="Cole S">S.P. Cole</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, J" uniqKey="Li J">J. Li</name></author><author><name sortKey="Li, Z N" uniqKey="Li Z">Z.N. Li</name></author><author><name sortKey="Du, Y J" uniqKey="Du Y">Y.J. Du</name></author><author><name sortKey="Li, X Q" uniqKey="Li X">X.Q. Li</name></author><author><name sortKey="Bao, Q L" uniqKey="Bao Q">Q.L. Bao</name></author><author><name sortKey="Chen, P" uniqKey="Chen P">P. Chen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Faggad, A" uniqKey="Faggad A">A. Faggad</name></author><author><name sortKey="Darb Esfahani, S" uniqKey="Darb Esfahani S">S. Darb-Esfahani</name></author><author><name sortKey="Wirtz, R" uniqKey="Wirtz R">R. Wirtz</name></author><author><name sortKey="Sinn, B" uniqKey="Sinn B">B. Sinn</name></author><author><name sortKey="Sehouli, J" uniqKey="Sehouli J">J. Sehouli</name></author><author><name sortKey="Konsgen, D" uniqKey="Konsgen D">D. Konsgen</name></author><author><name sortKey="Lage, H" uniqKey="Lage H">H. Lage</name></author><author><name sortKey="Noske, A" uniqKey="Noske A">A. Noske</name></author><author><name sortKey="Weichert, W" uniqKey="Weichert W">W. Weichert</name></author><author><name sortKey="Buckendahl, A C" uniqKey="Buckendahl A">A.C. Buckendahl</name></author><author><name sortKey="Budczies, J" uniqKey="Budczies J">J. Budczies</name></author><author><name sortKey="Muller, B M" uniqKey="Muller B">B.M. Muller</name></author><author><name sortKey="Elwali, N E" uniqKey="Elwali N">N.E. Elwali</name></author><author><name sortKey="Dietel, M" uniqKey="Dietel M">M. Dietel</name></author><author><name sortKey="Denkert, C" uniqKey="Denkert C">C. Denkert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Atalay, C" uniqKey="Atalay C">C. Atalay</name></author><author><name sortKey="Demirkazik, A" uniqKey="Demirkazik A">A. Demirkazik</name></author><author><name sortKey="Gunduz, U" uniqKey="Gunduz U">U. Gunduz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haber, M" uniqKey="Haber M">M. Haber</name></author><author><name sortKey="Smith, J" uniqKey="Smith J">J. Smith</name></author><author><name sortKey="Bordow, S B" uniqKey="Bordow S">S.B. Bordow</name></author><author><name sortKey="Flemming, C" uniqKey="Flemming C">C. Flemming</name></author><author><name sortKey="Cohn, S L" uniqKey="Cohn S">S.L. Cohn</name></author><author><name sortKey="London, W B" uniqKey="London W">W.B. London</name></author><author><name sortKey="Marshall, G M" uniqKey="Marshall G">G.M. Marshall</name></author><author><name sortKey="Norris, M D" uniqKey="Norris M">M.D. Norris</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Consoli, U" uniqKey="Consoli U">U. Consoli</name></author><author><name sortKey="Santonocito, A" uniqKey="Santonocito A">A. Santonocito</name></author><author><name sortKey="Stagno, F" uniqKey="Stagno F">F. Stagno</name></author><author><name sortKey="Fiumara, P" uniqKey="Fiumara P">P. Fiumara</name></author><author><name sortKey="Privitera, A" uniqKey="Privitera A">A. Privitera</name></author><author><name sortKey="Parisi, G" uniqKey="Parisi G">G. Parisi</name></author><author><name sortKey="Giustolisi, G M" uniqKey="Giustolisi G">G.M. Giustolisi</name></author><author><name sortKey="Pavone, B" uniqKey="Pavone B">B. Pavone</name></author><author><name sortKey="Palumbo, G A" uniqKey="Palumbo G">G.A. Palumbo</name></author><author><name sortKey="Di Raimondo, F" uniqKey="Di Raimondo F">F. Di Raimondo</name></author><author><name sortKey="Milone, G" uniqKey="Milone G">G. Milone</name></author><author><name sortKey="Guglielmo, P" uniqKey="Guglielmo P">P. Guglielmo</name></author><author><name sortKey="Giustolisi, R" uniqKey="Giustolisi R">R. Giustolisi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sullivan, G F" uniqKey="Sullivan G">G.F. Sullivan</name></author><author><name sortKey="Amenta, P S" uniqKey="Amenta P">P.S. Amenta</name></author><author><name sortKey="Villanueva, J D" uniqKey="Villanueva J">J.D. Villanueva</name></author><author><name sortKey="Alvarez, C J" uniqKey="Alvarez C">C.J. Alvarez</name></author><author><name sortKey="Yang, J M" uniqKey="Yang J">J.M. Yang</name></author><author><name sortKey="Hait, W N" uniqKey="Hait W">W.N. Hait</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurata, T" uniqKey="Kurata T">T. Kurata</name></author><author><name sortKey="Muraki, Y" uniqKey="Muraki Y">Y. Muraki</name></author><author><name sortKey="Mizutani, H" uniqKey="Mizutani H">H. Mizutani</name></author><author><name sortKey="Iwamoto, T" uniqKey="Iwamoto T">T. Iwamoto</name></author><author><name sortKey="Okuda, M" uniqKey="Okuda M">M. Okuda</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country><region><li>Guangdong</li></region><settlement><li>Jiangmen</li></settlement></list><tree><country name="République populaire de Chine"><region name="Guangdong"><name sortKey="Zhao, Ya" sort="Zhao, Ya" uniqKey="Zhao Y" first="Ya" last="Zhao">Ya Zhao</name></region><name sortKey="Feng, Limin" sort="Feng, Limin" uniqKey="Feng L" first="Limin" last="Feng">Limin Feng</name><name sortKey="Liu, Lijuan" sort="Liu, Lijuan" uniqKey="Liu L" first="Lijuan" last="Liu">Lijuan Liu</name><name sortKey="Zhao, Ruizhi" sort="Zhao, Ruizhi" uniqKey="Zhao R" first="Ruizhi" last="Zhao">Ruizhi Zhao</name><name sortKey="Zhao, Ruizhi" sort="Zhao, Ruizhi" uniqKey="Zhao R" first="Ruizhi" last="Zhao">Ruizhi Zhao</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/CovidV2/Data/new/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000687 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/new/Analysis/biblio.hfd -nk 000687 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= CovidV2
|flux= new
|étape= Analysis
|type= RBID
|clé= PMC:7094655
|texte= Saikosaponin b2 enhances the hepatotargeting effect of anticancer drugs through inhibition of multidrug resistance-associated drug transporters
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/new/Analysis/RBID.i -Sk "pubmed:31194994" \
| HfdSelect -Kh $EXPLOR_AREA/Data/new/Analysis/biblio.hfd \
| NlmPubMed2Wicri -a CovidV2
| This area was generated with Dilib version V0.6.33. |  |